#!/usr/bin/env python3
"""
Multivariate Analysis Script for Protocol Bicorder Data

Performs comprehensive multivariate statistical analyses on protocol diagnostic data,
including clustering, dimensionality reduction, correlation analysis, and visualization.

Usage:
    python3 multivariate_analysis.py diagnostic_output.csv [--analyses all]
    python3 multivariate_analysis.py diagnostic_output.csv --analyses clustering pca
"""

import argparse
import sys
from pathlib import Path
import warnings
warnings.filterwarnings('ignore')

import pandas as pd
import numpy as np
import matplotlib.pyplot as plt
import seaborn as sns
from scipy import stats
from scipy.cluster.hierarchy import dendrogram, linkage, fcluster
from scipy.spatial.distance import pdist, squareform
import networkx as nx

from sklearn.preprocessing import StandardScaler
from sklearn.decomposition import PCA, FactorAnalysis
from sklearn.manifold import TSNE
from sklearn.cluster import KMeans, DBSCAN, AgglomerativeClustering
from sklearn.ensemble import RandomForestClassifier
from sklearn.discriminant_analysis import LinearDiscriminantAnalysis
from sklearn.metrics import silhouette_score, davies_bouldin_score

try:
    import umap
    UMAP_AVAILABLE = True
except ImportError:
    UMAP_AVAILABLE = False
    print("Note: UMAP not available. Install with: pip install umap-learn")


class ProtocolAnalyzer:
    """Main class for multivariate analysis of protocol data."""

    def __init__(self, csv_path, output_dir='analysis_results'):
        """Initialize analyzer with data and output directory."""
        self.csv_path = Path(csv_path)
        self.output_dir = Path(output_dir)
        self.output_dir.mkdir(exist_ok=True)

        # Create subdirectories
        (self.output_dir / 'plots').mkdir(exist_ok=True)
        (self.output_dir / 'data').mkdir(exist_ok=True)
        (self.output_dir / 'reports').mkdir(exist_ok=True)

        # Load and prepare data
        self.df = None
        self.dimension_cols = []
        self.design_cols = []
        self.entanglement_cols = []
        self.experience_cols = []
        self.scaled_data = None
        self.scaler = None

        self._load_data()

    def _load_data(self):
        """Load CSV and identify dimension columns."""
        print(f"Loading data from {self.csv_path}...")
        self.df = pd.read_csv(self.csv_path)

        # Identify dimension columns
        all_cols = self.df.columns.tolist()
        self.design_cols = [c for c in all_cols if c.startswith('Design_')]
        self.entanglement_cols = [c for c in all_cols if c.startswith('Entanglement_')]
        self.experience_cols = [c for c in all_cols if c.startswith('Experience_')]
        self.dimension_cols = self.design_cols + self.entanglement_cols + self.experience_cols

        print(f"Loaded {len(self.df)} protocols with {len(self.dimension_cols)} dimensions")
        print(f"  - Design: {len(self.design_cols)}")
        print(f"  - Entanglement: {len(self.entanglement_cols)}")
        print(f"  - Experience: {len(self.experience_cols)}")

        # Check for missing values
        missing_count = self.df[self.dimension_cols].isna().sum().sum()
        rows_with_missing = self.df[self.dimension_cols].isna().any(axis=1).sum()

        if missing_count > 0:
            print(f"\nWarning: Found {missing_count} missing values in {rows_with_missing} rows")
            print("Dropping rows with missing values...")
            self.df = self.df.dropna(subset=self.dimension_cols)
            print(f"Dataset now contains {len(self.df)} protocols")

        # Standardize the dimension data
        self.scaler = StandardScaler()
        self.scaled_data = self.scaler.fit_transform(self.df[self.dimension_cols])

    def save_results(self, data, filename, subdir='data'):
        """Save results to CSV file."""
        output_path = self.output_dir / subdir / filename
        if isinstance(data, pd.DataFrame):
            data.to_csv(output_path, index=False)
        else:
            pd.DataFrame(data).to_csv(output_path)
        print(f"  Saved: {output_path}")

    def save_plot(self, filename):
        """Save current matplotlib figure."""
        output_path = self.output_dir / 'plots' / filename
        plt.tight_layout()
        plt.savefig(output_path, dpi=300, bbox_inches='tight')
        print(f"  Saved: {output_path}")
        plt.close()

    # ========== CLUSTERING ANALYSES ==========

    def kmeans_clustering(self, n_clusters_range=(2, 10)):
        """Perform K-means clustering with elbow method."""
        print("\n=== K-Means Clustering ===")

        # Elbow method
        inertias = []
        silhouettes = []
        k_range = range(n_clusters_range[0], n_clusters_range[1] + 1)

        for k in k_range:
            kmeans = KMeans(n_clusters=k, random_state=42, n_init=10)
            labels = kmeans.fit_predict(self.scaled_data)
            inertias.append(kmeans.inertia_)
            if k > 1:
                silhouettes.append(silhouette_score(self.scaled_data, labels))
            else:
                silhouettes.append(0)

        # Plot elbow curve
        fig, (ax1, ax2) = plt.subplots(1, 2, figsize=(14, 5))

        ax1.plot(k_range, inertias, 'bo-')
        ax1.set_xlabel('Number of Clusters (k)')
        ax1.set_ylabel('Inertia')
        ax1.set_title('Elbow Method for Optimal k')
        ax1.grid(True, alpha=0.3)

        ax2.plot(k_range, silhouettes, 'ro-')
        ax2.set_xlabel('Number of Clusters (k)')
        ax2.set_ylabel('Silhouette Score')
        ax2.set_title('Silhouette Score by k')
        ax2.grid(True, alpha=0.3)

        self.save_plot('kmeans_elbow.png')

        # Use optimal k (highest silhouette)
        optimal_k = k_range[np.argmax(silhouettes)]
        print(f"Optimal k by silhouette score: {optimal_k}")

        # Final clustering
        kmeans = KMeans(n_clusters=optimal_k, random_state=42, n_init=10)
        self.df['kmeans_cluster'] = kmeans.fit_predict(self.scaled_data)

        # Save results
        results = self.df[['Descriptor', 'kmeans_cluster']].copy()
        results['cluster'] = results['kmeans_cluster'] + 1  # 1-indexed for readability
        self.save_results(results[['Descriptor', 'cluster']], 'kmeans_clusters.csv')

        # Cluster statistics
        print(f"\nCluster sizes:")
        print(self.df['kmeans_cluster'].value_counts().sort_index())

        return self.df['kmeans_cluster']

    def hierarchical_clustering(self, n_clusters=5, method='ward'):
        """Perform hierarchical clustering with dendrogram."""
        print("\n=== Hierarchical Clustering ===")

        # Compute linkage
        Z = linkage(self.scaled_data, method=method)

        # Plot dendrogram
        plt.figure(figsize=(16, 8))
        dendrogram(Z, labels=self.df['Descriptor'].values, leaf_font_size=8)
        plt.title(f'Hierarchical Clustering Dendrogram ({method} linkage)')
        plt.xlabel('Protocol')
        plt.ylabel('Distance')
        plt.xticks(rotation=90)
        self.save_plot('hierarchical_dendrogram.png')

        # Cut tree to get clusters
        self.df['hierarchical_cluster'] = fcluster(Z, n_clusters, criterion='maxclust')

        # Save results
        results = self.df[['Descriptor', 'hierarchical_cluster']].copy()
        results.columns = ['Descriptor', 'cluster']
        self.save_results(results, 'hierarchical_clusters.csv')

        print(f"\nCluster sizes:")
        print(self.df['hierarchical_cluster'].value_counts().sort_index())

        return self.df['hierarchical_cluster']

    def dbscan_clustering(self, eps=3.0, min_samples=3):
        """Perform DBSCAN clustering to identify outliers."""
        print("\n=== DBSCAN Clustering ===")

        dbscan = DBSCAN(eps=eps, min_samples=min_samples)
        self.df['dbscan_cluster'] = dbscan.fit_predict(self.scaled_data)

        n_clusters = len(set(self.df['dbscan_cluster'])) - (1 if -1 in self.df['dbscan_cluster'] else 0)
        n_outliers = (self.df['dbscan_cluster'] == -1).sum()

        print(f"Found {n_clusters} clusters and {n_outliers} outliers")

        # Save results
        results = self.df[['Descriptor', 'dbscan_cluster']].copy()
        results.columns = ['Descriptor', 'cluster']
        self.save_results(results, 'dbscan_clusters.csv')

        if n_outliers > 0:
            outliers = self.df[self.df['dbscan_cluster'] == -1][['Descriptor']]
            self.save_results(outliers, 'dbscan_outliers.csv')
            print("\nOutlier protocols:")
            for protocol in outliers['Descriptor']:
                print(f"  - {protocol}")

        return self.df['dbscan_cluster']

    # ========== DIMENSIONALITY REDUCTION ==========

    def pca_analysis(self, n_components=None):
        """Perform PCA and visualize results."""
        print("\n=== Principal Component Analysis ===")

        # Fit PCA
        if n_components is None:
            pca = PCA()
        else:
            pca = PCA(n_components=n_components)

        pca_coords = pca.fit_transform(self.scaled_data)

        # Explained variance
        explained_var = pca.explained_variance_ratio_
        cumsum_var = np.cumsum(explained_var)

        print(f"First 5 PCs explain {cumsum_var[4]*100:.1f}% of variance")

        # Plot explained variance
        fig, (ax1, ax2) = plt.subplots(1, 2, figsize=(14, 5))

        n_show = min(15, len(explained_var))
        ax1.bar(range(1, n_show + 1), explained_var[:n_show])
        ax1.set_xlabel('Principal Component')
        ax1.set_ylabel('Explained Variance Ratio')
        ax1.set_title('Variance Explained by Each PC')
        ax1.grid(True, alpha=0.3, axis='y')

        ax2.plot(range(1, n_show + 1), cumsum_var[:n_show], 'o-')
        ax2.axhline(y=0.8, color='r', linestyle='--', alpha=0.5, label='80% threshold')
        ax2.set_xlabel('Number of Components')
        ax2.set_ylabel('Cumulative Explained Variance')
        ax2.set_title('Cumulative Variance Explained')
        ax2.legend()
        ax2.grid(True, alpha=0.3)

        self.save_plot('pca_variance.png')

        # 2D visualization
        plt.figure(figsize=(12, 10))
        plt.scatter(pca_coords[:, 0], pca_coords[:, 1], alpha=0.6, s=50)

        # Annotate points
        for i, protocol in enumerate(self.df['Descriptor']):
            if i % 3 == 0:  # Label every 3rd point to avoid clutter
                plt.annotate(protocol, (pca_coords[i, 0], pca_coords[i, 1]),
                           fontsize=6, alpha=0.7)

        plt.xlabel(f'PC1 ({explained_var[0]*100:.1f}% variance)')
        plt.ylabel(f'PC2 ({explained_var[1]*100:.1f}% variance)')
        plt.title('Protocols in PCA Space (First 2 Components)')
        plt.grid(True, alpha=0.3)
        self.save_plot('pca_2d.png')

        # Save PCA coordinates
        pca_df = pd.DataFrame(pca_coords[:, :5],
                             columns=[f'PC{i+1}' for i in range(min(5, pca_coords.shape[1]))])
        pca_df.insert(0, 'Descriptor', self.df['Descriptor'])
        self.save_results(pca_df, 'pca_coordinates.csv')

        # Component loadings
        loadings = pd.DataFrame(
            pca.components_[:5, :].T,
            columns=[f'PC{i+1}' for i in range(min(5, pca.components_.shape[0]))],
            index=self.dimension_cols
        )
        self.save_results(loadings, 'pca_loadings.csv')

        # Plot loadings heatmap
        plt.figure(figsize=(10, 12))
        sns.heatmap(loadings, cmap='RdBu_r', center=0, cbar_kws={'label': 'Loading'})
        plt.title('PCA Component Loadings')
        plt.tight_layout()
        self.save_plot('pca_loadings_heatmap.png')

        return pca_coords, pca

    def tsne_analysis(self, perplexity=30, n_components=2):
        """Perform t-SNE analysis."""
        print("\n=== t-SNE Analysis ===")

        tsne = TSNE(n_components=n_components, perplexity=perplexity, random_state=42, max_iter=1000)
        tsne_coords = tsne.fit_transform(self.scaled_data)

        # Plot
        plt.figure(figsize=(12, 10))
        plt.scatter(tsne_coords[:, 0], tsne_coords[:, 1], alpha=0.6, s=50)

        # Annotate some points
        for i, protocol in enumerate(self.df['Descriptor']):
            if i % 4 == 0:  # Label every 4th point
                plt.annotate(protocol, (tsne_coords[i, 0], tsne_coords[i, 1]),
                           fontsize=6, alpha=0.7)

        plt.xlabel('t-SNE Dimension 1')
        plt.ylabel('t-SNE Dimension 2')
        plt.title(f't-SNE Projection (perplexity={perplexity})')
        plt.grid(True, alpha=0.3)
        self.save_plot('tsne_2d.png')

        # Save coordinates
        tsne_df = pd.DataFrame(tsne_coords, columns=['TSNE1', 'TSNE2'])
        tsne_df.insert(0, 'Descriptor', self.df['Descriptor'])
        self.save_results(tsne_df, 'tsne_coordinates.csv')

        return tsne_coords

    def umap_analysis(self, n_neighbors=15, min_dist=0.1, n_components=2):
        """Perform UMAP analysis if available."""
        if not UMAP_AVAILABLE:
            print("\n=== UMAP Analysis ===")
            print("UMAP not available. Install with: pip install umap-learn")
            return None

        print("\n=== UMAP Analysis ===")

        reducer = umap.UMAP(n_neighbors=n_neighbors, min_dist=min_dist,
                           n_components=n_components, random_state=42)
        umap_coords = reducer.fit_transform(self.scaled_data)

        # Plot
        plt.figure(figsize=(12, 10))
        plt.scatter(umap_coords[:, 0], umap_coords[:, 1], alpha=0.6, s=50)

        # Annotate some points
        for i, protocol in enumerate(self.df['Descriptor']):
            if i % 4 == 0:
                plt.annotate(protocol, (umap_coords[i, 0], umap_coords[i, 1]),
                           fontsize=6, alpha=0.7)

        plt.xlabel('UMAP Dimension 1')
        plt.ylabel('UMAP Dimension 2')
        plt.title(f'UMAP Projection (n_neighbors={n_neighbors}, min_dist={min_dist})')
        plt.grid(True, alpha=0.3)
        self.save_plot('umap_2d.png')

        # Save coordinates
        umap_df = pd.DataFrame(umap_coords, columns=['UMAP1', 'UMAP2'])
        umap_df.insert(0, 'Descriptor', self.df['Descriptor'])
        self.save_results(umap_df, 'umap_coordinates.csv')

        return umap_coords

    def factor_analysis(self, n_factors=5):
        """Perform factor analysis."""
        print("\n=== Factor Analysis ===")

        fa = FactorAnalysis(n_components=n_factors, random_state=42)
        fa_coords = fa.fit_transform(self.scaled_data)

        # Factor loadings
        loadings = pd.DataFrame(
            fa.components_.T,
            columns=[f'Factor{i+1}' for i in range(n_factors)],
            index=self.dimension_cols
        )
        self.save_results(loadings, 'factor_loadings.csv')

        # Plot loadings heatmap
        plt.figure(figsize=(10, 12))
        sns.heatmap(loadings, cmap='RdBu_r', center=0, cbar_kws={'label': 'Loading'})
        plt.title('Factor Analysis Loadings')
        plt.tight_layout()
        self.save_plot('factor_loadings_heatmap.png')

        # Save factor scores
        fa_df = pd.DataFrame(fa_coords,
                            columns=[f'Factor{i+1}' for i in range(n_factors)])
        fa_df.insert(0, 'Descriptor', self.df['Descriptor'])
        self.save_results(fa_df, 'factor_scores.csv')

        return fa_coords, fa

    # ========== CORRELATION & STRUCTURE ==========

    def correlation_analysis(self):
        """Compute and visualize correlation matrices."""
        print("\n=== Correlation Analysis ===")

        # Full correlation matrix
        corr_matrix = self.df[self.dimension_cols].corr()

        # Plot full correlation heatmap
        plt.figure(figsize=(16, 14))
        sns.heatmap(corr_matrix, cmap='RdBu_r', center=0,
                   square=True, linewidths=0.5, cbar_kws={'label': 'Correlation'})
        plt.title('Correlation Matrix - All Dimensions')
        plt.tight_layout()
        self.save_plot('correlation_heatmap_full.png')

        # Save correlation matrix
        self.save_results(corr_matrix, 'correlation_matrix.csv')

        # Find strongest correlations
        corr_pairs = []
        for i in range(len(corr_matrix.columns)):
            for j in range(i+1, len(corr_matrix.columns)):
                corr_pairs.append({
                    'Dimension1': corr_matrix.columns[i],
                    'Dimension2': corr_matrix.columns[j],
                    'Correlation': corr_matrix.iloc[i, j]
                })

        corr_df = pd.DataFrame(corr_pairs).sort_values('Correlation',
                                                       key=abs,
                                                       ascending=False)
        self.save_results(corr_df.head(20), 'top_correlations.csv')

        print("\nTop 5 positive correlations:")
        for _, row in corr_df.head(5).iterrows():
            print(f"  {row['Dimension1']} <-> {row['Dimension2']}: {row['Correlation']:.3f}")

        print("\nTop 5 negative correlations:")
        for _, row in corr_df.tail(5).iterrows():
            print(f"  {row['Dimension1']} <-> {row['Dimension2']}: {row['Correlation']:.3f}")

        # Within-category correlations
        self._plot_category_correlation('Design', self.design_cols)
        self._plot_category_correlation('Entanglement', self.entanglement_cols)
        self._plot_category_correlation('Experience', self.experience_cols)

        return corr_matrix

    def _plot_category_correlation(self, category_name, columns):
        """Plot correlation heatmap for a specific category."""
        corr = self.df[columns].corr()

        plt.figure(figsize=(10, 8))
        sns.heatmap(corr, annot=True, fmt='.2f', cmap='RdBu_r', center=0,
                   square=True, linewidths=0.5, cbar_kws={'label': 'Correlation'})
        plt.title(f'{category_name} Dimensions - Correlation Matrix')
        plt.tight_layout()
        self.save_plot(f'correlation_heatmap_{category_name.lower()}.png')

    def network_analysis(self, threshold=0.5):
        """Create network graph of protocol similarities."""
        print("\n=== Network Analysis ===")

        # Compute pairwise distances
        distances = pdist(self.scaled_data, metric='euclidean')
        dist_matrix = squareform(distances)

        # Convert to similarity (inverse of distance, normalized)
        max_dist = dist_matrix.max()
        similarity_matrix = 1 - (dist_matrix / max_dist)

        # Create network
        G = nx.Graph()

        # Add nodes
        for i, protocol in enumerate(self.df['Descriptor']):
            G.add_node(i, label=protocol)

        # Add edges above threshold
        edge_count = 0
        for i in range(len(similarity_matrix)):
            for j in range(i+1, len(similarity_matrix)):
                if similarity_matrix[i, j] > threshold:
                    G.add_edge(i, j, weight=similarity_matrix[i, j])
                    edge_count += 1

        print(f"Network with {G.number_of_nodes()} nodes and {edge_count} edges")

        # Calculate network metrics
        if G.number_of_edges() > 0:
            degree_centrality = nx.degree_centrality(G)
            betweenness = nx.betweenness_centrality(G)

            metrics_df = pd.DataFrame({
                'Descriptor': [self.df.iloc[i]['Descriptor'] for i in G.nodes()],
                'Degree_Centrality': [degree_centrality[i] for i in G.nodes()],
                'Betweenness_Centrality': [betweenness[i] for i in G.nodes()]
            }).sort_values('Degree_Centrality', ascending=False)

            self.save_results(metrics_df, 'network_metrics.csv')

            print("\nTop 5 most central protocols:")
            for _, row in metrics_df.head(5).iterrows():
                print(f"  {row['Descriptor']}: {row['Degree_Centrality']:.3f}")

            # Plot network
            plt.figure(figsize=(16, 16))
            pos = nx.spring_layout(G, k=0.5, iterations=50, seed=42)

            # Node sizes based on degree centrality
            node_sizes = [degree_centrality[i] * 3000 + 100 for i in G.nodes()]

            nx.draw_networkx_nodes(G, pos, node_size=node_sizes,
                                  node_color='lightblue', alpha=0.7)
            nx.draw_networkx_edges(G, pos, alpha=0.2)

            # Labels for high-centrality nodes
            high_centrality = {i: self.df.iloc[i]['Descriptor']
                             for i in G.nodes() if degree_centrality[i] > 0.1}
            nx.draw_networkx_labels(G, pos, labels=high_centrality, font_size=8)

            plt.title(f'Protocol Similarity Network (threshold={threshold})')
            plt.axis('off')
            plt.tight_layout()
            self.save_plot('network_graph.png')
        else:
            print("No edges above threshold - try lowering the threshold")

        return G

    # ========== CLASSIFICATION & PREDICTION ==========

    def category_discriminant_analysis(self):
        """Analyze how well dimension categories discriminate protocols."""
        print("\n=== Category Discriminant Analysis ===")

        results = []

        for category_name, columns in [('Design', self.design_cols),
                                       ('Entanglement', self.entanglement_cols),
                                       ('Experience', self.experience_cols)]:

            # Use one category to predict clustering from another
            X = self.df[columns].values

            # Use kmeans clusters as target if available
            if 'kmeans_cluster' in self.df.columns:
                y = self.df['kmeans_cluster'].values

                # LDA
                try:
                    lda = LinearDiscriminantAnalysis()
                    lda.fit(X, y)
                    score = lda.score(X, y)

                    results.append({
                        'Category': category_name,
                        'Accuracy': score,
                        'N_Dimensions': len(columns)
                    })

                    print(f"{category_name} dimensions predict clusters with {score*100:.1f}% accuracy")
                except:
                    print(f"Could not perform LDA for {category_name}")

        if results:
            results_df = pd.DataFrame(results)
            self.save_results(results_df, 'category_discriminant_results.csv')

        return results

    def feature_importance_analysis(self):
        """Analyze which dimensions are most important for clustering."""
        print("\n=== Feature Importance Analysis ===")

        if 'kmeans_cluster' not in self.df.columns:
            print("Run clustering first to enable feature importance analysis")
            return None

        # Random Forest classifier
        X = self.df[self.dimension_cols].values
        y = self.df['kmeans_cluster'].values

        rf = RandomForestClassifier(n_estimators=100, random_state=42)
        rf.fit(X, y)

        # Feature importances
        importances = pd.DataFrame({
            'Dimension': self.dimension_cols,
            'Importance': rf.feature_importances_
        }).sort_values('Importance', ascending=False)

        self.save_results(importances, 'feature_importances.csv')

        # Plot top 20
        plt.figure(figsize=(10, 12))
        top_20 = importances.head(20)
        plt.barh(range(len(top_20)), top_20['Importance'])
        plt.yticks(range(len(top_20)), top_20['Dimension'])
        plt.xlabel('Importance')
        plt.title('Top 20 Most Important Dimensions for Clustering')
        plt.gca().invert_yaxis()
        plt.tight_layout()
        self.save_plot('feature_importances.png')

        print("\nTop 10 most important dimensions:")
        for _, row in importances.head(10).iterrows():
            print(f"  {row['Dimension']}: {row['Importance']:.4f}")

        return importances

    def analyst_comparison(self):
        """Compare ratings across different analysts."""
        print("\n=== Analyst Comparison ===")

        if 'analyst' not in self.df.columns:
            print("No analyst column found")
            return None

        analysts = self.df['analyst'].unique()
        print(f"Found {len(analysts)} unique analysts")

        # Mean ratings by analyst for each dimension
        analyst_means = self.df.groupby('analyst')[self.dimension_cols].mean()
        self.save_results(analyst_means, 'analyst_mean_ratings.csv')

        # Plot comparison
        fig, axes = plt.subplots(3, 1, figsize=(14, 12))

        for idx, (category_name, columns) in enumerate([
            ('Design', self.design_cols),
            ('Entanglement', self.entanglement_cols),
            ('Experience', self.experience_cols)
        ]):
            analyst_means[columns].T.plot(ax=axes[idx], marker='o')
            axes[idx].set_title(f'{category_name} Dimensions - Mean Ratings by Analyst')
            axes[idx].set_ylabel('Mean Rating')
            axes[idx].legend(title='Analyst', bbox_to_anchor=(1.05, 1), loc='upper left')
            axes[idx].grid(True, alpha=0.3)
            axes[idx].set_xticklabels(axes[idx].get_xticklabels(), rotation=45, ha='right')

        plt.tight_layout()
        self.save_plot('analyst_comparison.png')

        return analyst_means

    # ========== SUMMARY REPORT ==========

    def generate_summary_report(self):
        """Generate a text summary of all analyses."""
        print("\n=== Generating Summary Report ===")

        report_lines = []
        report_lines.append("=" * 80)
        report_lines.append("MULTIVARIATE ANALYSIS SUMMARY REPORT")
        report_lines.append("Protocol Bicorder Dataset")
        report_lines.append("=" * 80)
        report_lines.append("")

        report_lines.append(f"Dataset: {self.csv_path}")
        report_lines.append(f"Number of protocols: {len(self.df)}")
        report_lines.append(f"Number of dimensions: {len(self.dimension_cols)}")
        report_lines.append(f"  - Design: {len(self.design_cols)}")
        report_lines.append(f"  - Entanglement: {len(self.entanglement_cols)}")
        report_lines.append(f"  - Experience: {len(self.experience_cols)}")
        report_lines.append("")

        report_lines.append("-" * 80)
        report_lines.append("ANALYSES PERFORMED")
        report_lines.append("-" * 80)

        # Check which analyses were run
        analyses_run = []

        if 'kmeans_cluster' in self.df.columns:
            analyses_run.append("- K-Means Clustering")
            report_lines.append(f"K-Means: {len(self.df['kmeans_cluster'].unique())} clusters identified")

        if 'hierarchical_cluster' in self.df.columns:
            analyses_run.append("- Hierarchical Clustering")
            report_lines.append(f"Hierarchical: {len(self.df['hierarchical_cluster'].unique())} clusters")

        if 'dbscan_cluster' in self.df.columns:
            analyses_run.append("- DBSCAN Clustering")
            n_outliers = (self.df['dbscan_cluster'] == -1).sum()
            report_lines.append(f"DBSCAN: {n_outliers} outlier protocols identified")

        report_lines.append("")
        report_lines.append("Dimensionality Reduction:")
        report_lines.append("- Principal Component Analysis (PCA)")
        report_lines.append("- t-SNE Projection")
        if UMAP_AVAILABLE:
            report_lines.append("- UMAP Projection")
        report_lines.append("- Factor Analysis")
        report_lines.append("")

        report_lines.append("Statistical Analyses:")
        report_lines.append("- Correlation Analysis")
        report_lines.append("- Network Analysis")
        report_lines.append("- Feature Importance Analysis")

        if 'analyst' in self.df.columns:
            report_lines.append("- Analyst Comparison")

        report_lines.append("")
        report_lines.append("-" * 80)
        report_lines.append("OUTPUT FILES")
        report_lines.append("-" * 80)
        report_lines.append(f"All results saved to: {self.output_dir}/")
        report_lines.append("  - plots/ : All visualizations (PNG)")
        report_lines.append("  - data/ : All numerical results (CSV)")
        report_lines.append("  - reports/ : This summary report")
        report_lines.append("")

        report_lines.append("=" * 80)
        report_lines.append("END OF REPORT")
        report_lines.append("=" * 80)

        report_text = "\n".join(report_lines)

        # Save report
        report_path = self.output_dir / 'reports' / 'analysis_summary.txt'
        with open(report_path, 'w') as f:
            f.write(report_text)

        print(f"  Saved: {report_path}")
        print("\n" + report_text)

        return report_text


def main():
    """Main execution function."""
    parser = argparse.ArgumentParser(
        description='Multivariate analysis of Protocol Bicorder data',
        formatter_class=argparse.RawDescriptionHelpFormatter,
        epilog="""
Examples:
  python3 multivariate_analysis.py diagnostic_output.csv
  python3 multivariate_analysis.py diagnostic_output.csv --output results/
  python3 multivariate_analysis.py diagnostic_output.csv --analyses clustering pca
        """
    )

    parser.add_argument('csv_file', help='Input CSV file with protocol diagnostics')
    parser.add_argument('--output', '-o', default='analysis_results',
                       help='Output directory (default: analysis_results)')
    parser.add_argument('--analyses', nargs='+',
                       choices=['clustering', 'pca', 'tsne', 'umap', 'factor',
                               'correlation', 'network', 'importance', 'analyst', 'all'],
                       default=['all'],
                       help='Which analyses to run (default: all)')

    args = parser.parse_args()

    # Check if file exists
    if not Path(args.csv_file).exists():
        print(f"Error: File not found: {args.csv_file}")
        sys.exit(1)

    # Initialize analyzer
    print("=" * 80)
    print("PROTOCOL BICORDER - MULTIVARIATE ANALYSIS")
    print("=" * 80)

    analyzer = ProtocolAnalyzer(args.csv_file, args.output)

    # Determine which analyses to run
    run_all = 'all' in args.analyses

    # Run analyses
    try:
        # Clustering
        if run_all or 'clustering' in args.analyses:
            analyzer.kmeans_clustering()
            analyzer.hierarchical_clustering()
            analyzer.dbscan_clustering()

        # Dimensionality reduction
        if run_all or 'pca' in args.analyses:
            analyzer.pca_analysis()

        if run_all or 'tsne' in args.analyses:
            analyzer.tsne_analysis()

        if run_all or 'umap' in args.analyses:
            analyzer.umap_analysis()

        if run_all or 'factor' in args.analyses:
            analyzer.factor_analysis()

        # Correlation and structure
        if run_all or 'correlation' in args.analyses:
            analyzer.correlation_analysis()

        if run_all or 'network' in args.analyses:
            analyzer.network_analysis(threshold=0.6)

        # Classification
        if run_all or 'importance' in args.analyses:
            analyzer.category_discriminant_analysis()
            analyzer.feature_importance_analysis()

        if run_all or 'analyst' in args.analyses:
            analyzer.analyst_comparison()

        # Generate summary
        analyzer.generate_summary_report()

        print("\n" + "=" * 80)
        print("ANALYSIS COMPLETE!")
        print("=" * 80)
        print(f"\nAll results saved to: {analyzer.output_dir}/")

    except Exception as e:
        print(f"\nError during analysis: {e}")
        import traceback
        traceback.print_exc()
        sys.exit(1)


if __name__ == '__main__':
    main()